Effects of mercury on Dictyostelium discoideum: proteomics reveals the molecular mechanisms of physiological adaptation and toxicity.

@article{Marsano2010EffectsOM,
  title={Effects of mercury on Dictyostelium discoideum: proteomics reveals the molecular mechanisms of physiological adaptation and toxicity.},
  author={F. Marsano and L. Boatti and E. Ranzato and M. Cavaletto and V. Magnelli and F. Dondero and A. Viarengo},
  journal={Journal of proteome research},
  year={2010},
  volume={9 6},
  pages={
          2839-54
        }
}
Dictyostelium discoideum amoebae were exposed to Hg 2 microM corresponding to a sublethal concentration and Hg 10 microM with the first effects on mortality and replication rate. A total of 900 spots were visualized by 2-DE electrophoresis. Two-hundred fifty single proteins were identified by mass spectrometry. Low Hg concentration (2 microM) treatment induced up-regulation of 13 spots, mainly involved in oxidative stress response/detoxification, oxidoreductase activity, and metabolic processes… Expand
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