Effects of mercurials on ligand- and voltage-gated ion channels: a review.

@article{Sirois1996EffectsOM,
  title={Effects of mercurials on ligand- and voltage-gated ion channels: a review.},
  author={Jay E Sirois and William David Atchison},
  journal={Neurotoxicology},
  year={1996},
  volume={17 1},
  pages={
          63-84
        }
}
Both organic and inorganic mercurials are neurotoxic, an action attributable to their prominent reactivity with numerous biological ligands. While many sites within the central nervous system can be potentially affected by mercurials, ligand-and voltage-gated ion channels represent a plausible early target. There are several reasons for this. First, ion channels are located on the plasma membrane in large numbers, thus increasing the likelihood of mercurial-channel interaction. Second, ion… CONTINUE READING

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