Effects of menthol and cold on histamine-induced itch and skin reactions in man

@article{Bromma1995EffectsOM,
  title={Effects of menthol and cold on histamine-induced itch and skin reactions in man},
  author={Burkhart Bromma and Eckehard Scharein and Ulf Darsow and J. Ring},
  journal={Neuroscience Letters},
  year={1995},
  volume={187},
  pages={157-160}
}
The effects of cooling and topical application of menthol on histamine-induced itch, wheal and flare reactions of the left lower arm were investigated in a threefold cross-over design with 15 healthy male volunteers. Lowering skin temperature by cooling from 32.8 +/- 0.3 degrees C to 29.7 +/- 0.5 degrees C reduced itch intensity from 260 +/- 47 units to 55 +/- 12 units (visual analogue scale) and flare diameters from 39.0 +/- 2.0 mm to 30.2 +/- 1.8 mm; wheal reactions were not affected. A… CONTINUE READING
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