Effects of memantine and galantamine on cognitive performance in aged rhesus macaques

@article{Schneider2013EffectsOM,
  title={Effects of memantine and galantamine on cognitive performance in aged rhesus macaques},
  author={Jay S Schneider and Elsa Y. Pioli and Yang Jianzhong and Qin Li and Erwan B{\'e}zard},
  journal={Neurobiology of Aging},
  year={2013},
  volume={34},
  pages={1126-1132}
}
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13 Citations
Background Citations
2
Methods Citations
1
Results Citations
1

13 Citations

Citation Type

Citation Type

Effects of acute administration of donepezil or memantine on sleep-deprivation-induced spatial memory deficit in young and aged non-human primate grey mouse lemurs (Microcebus murinus)
TLDR
The results indicate that two widely used drugs for mitigating cognitive deficits in AD were partially effective in sleep deprived mouse lemurs, which further support the translational potential of this animal model.
Galantamine-Memantine combination in the treatment of Alzheimer's disease and beyond
  • M. Koola
  • Biology, Medicine
    Psychiatry Research
  • 2020
Potential Role of Antipsychotic-Galantamine-Memantine Combination in the Treatment of Positive, Cognitive, and Negative Symptoms of Schizophrenia
  • M. Koola
  • Psychology, Medicine
    Molecular Neuropsychiatry
  • 2018
TLDR
The objective of this article is to critically dissect the published randomized controlled trials with galantamine and memantine for CIAS to highlight the efficacy signal and suggest a “low-risk high-gain” approach that could be a major breakthrough in the field.
The combination of memantine and galantamine improves cognition in rats: The synergistic role of the α7 nicotinic acetylcholine and NMDA receptors
Galantamine-memantine combination superior to donepezil-memantine combination in Alzheimer’s disease: critical dissection with an emphasis on kynurenic acid and mismatch negativity
TLDR
Galantamine and memantine via the α7nACh and NMDA receptors can counteract the effects of kynurenic acid and enhance MMN and BDNF and future studies with the galantamine-memantine combination with KP metabolites, MMN, andBDNF as biomarkers are warranted.
Why bother using non-human primate models of cognitive disorders in translational research?
Cognitive Enhancer Effects of Low Memantine Doses Are Facilitated by an Alpha7 Nicotinic Acetylcholine Receptor Agonist in Scopolamine-Induced Amnesia in Rats
TLDR
The results suggest that memantine and PHA-543613 may exert their cognitive enhancer effects on the same target, possibly on the alpha7 nAChRs.
Chronic manganese exposure impairs visuospatial associative learning in non-human primates.
The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline
Converging models of schizophrenia – Network alterations of prefrontal cortex underlying cognitive impairments
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