Effects of melatonin receptor ligands on swim test immobility

@article{Overstreet1998EffectsOM,
  title={Effects of melatonin receptor ligands on swim test immobility},
  author={David H. Overstreet and Olgierd Puciłowski and Marie-Claire Retton and Philippe Delagrange and B{\'e}atrice Guardiola‐Lema{\^i}tre},
  journal={NeuroReport},
  year={1998},
  volume={9},
  pages={249–253}
}
THE Flinders Sensitive Line (FSL) rats have been proposed as a genetic animal model of depression because their innately high immobility in the forced swim test is counteracted by antidepressants. This model was used to test the acute and chronic effects of two novel compounds which have either an agonist or antagonist-like effect at melatonin receptors. In the acute study FSL and control Flinders Resistant Line (FRL) rats were unaffected by either the agonist S 20304 (1 or 20 mg/kg) or the… 
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