Effects of melatonin on sleep and neurochemistry in the rat.

  title={Effects of melatonin on sleep and neurochemistry in the rat.},
  author={S. W. Holmes and David Sugden},
  journal={British journal of pharmacology},
  volume={76 1},
1 The effects of intraperitoneally administered melatonin on sleep and brain neurochemistry in the rat were studied by use of EEG recording and standard fluorescence techniques. 2 Melatonin, 10 mg/kg, reduced time to sleep onset and time spent awake but increased both slow wave and paradoxical sleep. Qualitatively similar but smaller effects were produced by a dose of 2.5 mg/kg. 3 Neither dose of melatonin altered normal EEG patterns or disrupted normal sleep behaviour. 4 Melatonin, 20 mg/Kg… CONTINUE READING
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