Effects of melatonin on DNA damage induced by cyclophosphamide in rats

  title={Effects of melatonin on DNA damage induced by cyclophosphamide in rats},
  author={Simone Gomes Ferreira and Rodrigo Antonio Peliciari-Garcia and S. A. Takahashi-Hyodo and Alice Cristina Rodrigues and Fernanda Gaspar do Amaral and Carolina M. Berra and Silvana Bordin and Rui Curi and Jos{\'e} Cipolla-Neto},
  journal={Brazilian Journal of Medical and Biological Research},
  pages={278 - 286}
The antioxidant and free radical scavenger properties of melatonin have been well described in the literature. In this study, our objective was to determine the protective effect of the pineal gland hormone against the DNA damage induced by cyclophosphamide (CP), an anti-tumor agent that is widely applied in clinical practice. DNA damage was induced in rats by a single intraperitoneal injection of CP (20 or 50 mg/kg). Animals received melatonin during the dark period for 15 days (1 mg/kg in the… 

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