Effects of melatonin on DNA damage induced by cyclophosphamide in rats

  title={Effects of melatonin on DNA damage induced by
cyclophosphamide in rats},
  author={S. Ferreira and R. A. Peliciari-Garcia and S. A. Takahashi-Hyodo and A. A. C. Rodrigues and F Amaral and C. M. Berra and Silvana Auxiliadora Bordin and R. A. Curi and Jos{\'e} Cipolla-Neto},
  booktitle={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
The antioxidant and free radical scavenger properties of melatonin have been well described in the literature. In this study, our objective was to determine the protective effect of the pineal gland hormone against the DNA damage induced by cyclophosphamide (CP), an anti-tumor agent that is widely applied in clinical practice. DNA damage was induced in rats by a single intraperitoneal injection of CP (20 or 50 mg/kg). Animals received melatonin during the dark period for 15 days (1 mg/kg in the… CONTINUE READING


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