Effects of melatonin combined with Cis-platinum or methotrexate on the proliferation of osteosarcoma cell line SaOS-2.

  title={Effects of melatonin combined with Cis-platinum or methotrexate on the proliferation of osteosarcoma cell line SaOS-2.},
  author={Ya-peng Wang and Zhipeng Yang},
  journal={Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae},
  volume={37 2},
  • Ya-peng Wang, Zhipeng Yang
  • Published 2015
  • Medicine, Chemistry
  • Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
OBJECTIVE To evaluate the effects of melatonin (Mel) combined with cis-platinum (DDP) or methotrexate (MTX) on the proliferation of osteosarcoma cell line SaOS-2, and to explore whether Mel combined with DDP or MTX could play a synergistic antitumor effect. METHODS SaOS-2 was treated with Mel alone or Mel combined with DDP or MTX. Cell counting kit-8 assay was used to measure the cell activities. Combination index(CI) value was used to evaluate the combined effects: CI<1 indicating synergetic… Expand
Melatonin Inhibits Osteoclastogenesis and Osteolytic Bone Metastasis: Implications for Osteoporosis
It appears that the therapeutic qualities of melatonin supplementation may enable existing antiresorptive osteoporotic drugs to treat osteolytic metastasis. Expand
Melatonin Suppresses Oral Squamous Cell Carcinomas Migration and Invasion through Blocking FGF19/FGFR 4 Signaling Pathway
  • Leilei Wang, Yuxiong Su, Wing Shan Choi
  • Medicine
  • International journal of molecular sciences
  • 2021
It is proved that melatonin suppresses SCC-15 cells invasion and migration through blocking the FGF19/FGFR4 pathway, which enriches the knowledge on the anticancer effects of melatonin. Expand
Melatonin and gastrointestinal cancers: Current evidence based on underlying signaling pathways.
It is suggested that melatonin in combination with anticancer agents may improve the efficacy of routine medicine and survival rate of patients with cancer. Expand
New insights into antimetastatic signaling pathways of melatonin in skeletomuscular sarcoma of childhood and adolescence
This state-of-the-art review compiled the knowledge related to the molecular mechanism of antimetastatic actions of melatonin on skeletomuscular sarcoma as in childhood and during adolescence. Expand
Molecular and Cellular Mechanisms of Melatonin in Osteosarcoma
The underlying mechanism of anti-osteosarcoma properties evoked by melatonin, including antioxidant activity, anti-proliferation, induction of apoptosis, and the inhibition of invasion and metastasis are highlighted. Expand
Melatonin May Increase Anticancer Potential of Pleiotropic Drugs
Adjuvant therapy with melatonin may improve the oncostatic potential of so-called pleiotropic drugs, which include non-steroidal anti-inflammatory drugs, statins and peroral antidiabetics. Expand
Melatonin attenuates osteosarcoma cell invasion by suppression of C‐C motif chemokine ligand 24 through inhibition of the c‐Jun N‐terminal kinase pathway
It is demonstrated that melatonin elicited very low cytotoxicity and significantly inhibited cellular motility, migration, and invasion in human osteosarcoma U2OS and HOS cells, highlighting the therapeutic potential of melatonin for osteosARcoma metastasis. Expand
Melatonin inhibits osteosarcoma stem cells by suppressing SOX9‐mediated signaling
In vivo mice model showed that melatonin significantly inhibits the initiation and metastasis of osteosarcoma, and in vitro results deepen the understanding of the biological functions of melatonin and provide new insights for the intervention of ostea stem cells. Expand
Melatonin and Hippo Pathway: Is There Existing Cross-Talk?
The structure and functions of melatonin and its receptors are described, and both molecular and epidemiological evidence on melatonin anticancer effects are discussed, to shed light on potential cross-talk between melatonin signaling and the Hippo signaling pathway. Expand