Effects of melatonin combined with Cis-platinum or methotrexate on the proliferation of osteosarcoma cell line SaOS-2.
@article{Wang2015EffectsOM, title={Effects of melatonin combined with Cis-platinum or methotrexate on the proliferation of osteosarcoma cell line SaOS-2.}, author={Ya-peng Wang and Zhipeng Yang}, journal={Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae}, year={2015}, volume={37 2}, pages={ 215-20 } }
OBJECTIVE
To evaluate the effects of melatonin (Mel) combined with cis-platinum (DDP) or methotrexate (MTX) on the proliferation of osteosarcoma cell line SaOS-2, and to explore whether Mel combined with DDP or MTX could play a synergistic antitumor effect.
METHODS
SaOS-2 was treated with Mel alone or Mel combined with DDP or MTX. Cell counting kit-8 assay was used to measure the cell activities. Combination index(CI) value was used to evaluate the combined effects: CI<1 indicating synergetic…
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