• DOI:10.3881/j.issn.1000-503X.2015.02.013
Corpus ID: 25999650

Effects of melatonin combined with Cis-platinum or methotrexate on the proliferation of osteosarcoma cell line SaOS-2.

@article{Wang2015EffectsOM,
  title={Effects of melatonin combined with Cis-platinum or methotrexate on the proliferation of osteosarcoma cell line SaOS-2.},
  author={Ya-peng Wang and Zhipeng Yang},
  journal={Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae},
  year={2015},
  volume={37 2},
  pages={
          215-20
        }
}

• Ya-peng Wang, Zhipeng Yang
• Published 2015
• Medicine, Chemistry
• Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

OBJECTIVE To evaluate the effects of melatonin (Mel) combined with cis-platinum (DDP) or methotrexate (MTX) on the proliferation of osteosarcoma cell line SaOS-2, and to explore whether Mel combined with DDP or MTX could play a synergistic antitumor effect. METHODS SaOS-2 was treated with Mel alone or Mel combined with DDP or MTX. Cell counting kit-8 assay was used to measure the cell activities. Combination index(CI) value was used to evaluate the combined effects: CI<1 indicating synergetic… Expand