Effects of melatonin administration to rats with glycerol-induced acute renal failure.

@article{Ferraz2002EffectsOM,
  title={Effects of melatonin administration to rats with glycerol-induced acute renal failure.},
  author={Fabia Fernandes Ferraz and Adilton Gomes Kos and Patr{\'i}cia Janino and Eduardo Homsi},
  journal={Renal failure},
  year={2002},
  volume={24 6},
  pages={735-46}
}
Melatonin, the pineal hormone with antioxidative properties was administered to rats with glycerol-induced myoglobinuric acute renal failure (Gly-ARF). This model is characterized by acute tubular necrosis mediated by heme-iron oxidative stress. Rats received melatonin (20 mg/kg) concomitant and 3 h after glycerol injection. Gly-ARF rats showed at 24 h a 78% reduction in glomerular filtration rate, whereas this decrement was significantly reduced to 35% in the melatonin treated Gly-ARF rats… CONTINUE READING