Effects of mefloquine on Ca2+ uptake and release by dog brain microsomes.

@article{Lee1996EffectsOM,
  title={Effects of mefloquine on Ca2+ uptake and release by dog brain microsomes.},
  author={How Sung Lee and Mei-Lin Go},
  journal={Archives internationales de pharmacodynamie et de therapie},
  year={1996},
  volume={331 3},
  pages={221-31}
}
The effects of the antimalarial drug, mefloquine, on the uptake and release of Ca2+ by crude microsomes from dog brain were investigated using a spectrophotometric method. Mefloquine inhibited the inositol-1,4,5-phosphate (IP3)-induced Ca2+ release with an IC50 of 42 microM, but was a weaker inhibitor of the uptake of Ca2+ into the vesicles (IC50: 272 microM). These effects of mefloquine are in contrast to its actions on Ca2+ uptake and release by skeletal muscle microsomes, where its… CONTINUE READING
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