Effects of medial septal lesions on an operant go/no-go delayed response alternation task in rats

@article{Numan1995EffectsOM,
  title={Effects of medial septal lesions on an operant go/no-go delayed response alternation task in rats},
  author={Robert Numan and Michael P. Feloney and Kelly H Pham and Lisa M Tieber},
  journal={Physiology \& Behavior},
  year={1995},
  volume={58},
  pages={1263-1271}
}
Effects of medial septal lesions on action-outcome associations in rats under conditions of delayed reinforcement.
TLDR
Under immediate contingent reinforcement, rats with medial septal lesions reduced their response rates, just like controls, when contingencies were shifted from positive toward zero, however, the sePTal rats were less sensitive to this contingency shift, compared with controls when there was a 5-s delay between lever presses and contingent reinforcements.
Blockade of central cholinergic receptors impairs new learning and increases proactive interference in a word paired-associate memory task.
TLDR
Evidence in humans supporting blockade of muscarinic cholinergic receptors impairs paired-associate learning and increases proactive interference is provided.
Neuromodulation, theta rhythm and rat spatial navigation
A Proposed Function for Hippocampal Theta Rhythm: Separate Phases of Encoding and Retrieval Enhance Reversal of Prior Learning
TLDR
A hippocampal model shows how theta rhythm could be important for reversal in this task by providing separate functional phases during each 100-300 msec cycle, consistent with physiological data.
Septal Modulation of the Working Memory for Voluntary Behavior
TLDR
In people, the semantic and episodic components of declarative memory might be modulated by different portions of the hippocampal system, with the hippocampus proper playing a stronger role in the regulation of episodic memory, whereas the perirhinal and parahippocampal cortex more strongly mediate semantic memory.
The Prefrontal-Hippocampal Comparator: Volition and Episodic Memory.
  • R. Numan
  • Psychology, Biology
    Perceptual and motor skills
  • 2021
This review describes recent research that is relevant to the prefrontal-hippocampal comparator model with the following conclusions: 1. Hippocampal area CA1 serves, at least in part, as an
A Prefrontal-Hippocampal Comparator for Goal-Directed Behavior: The Intentional Self and Episodic Memory
  • R. Numan
  • Psychology, Biology
    Front. Behav. Neurosci.
  • 2015
The hypothesis of this article is that the interactions between the prefrontal cortex and the hippocampus play a critical role in the modulation of goal-directed self-action and the strengthening of
The Prefrontal-Hippocampal Comparator: Volition and Episodic Memory
TLDR
This review article supports the following: Hippocampal area CA1 serves as an associative match-mismatch comparator, Voluntary movement strengthens episodic memories for goal-directed behavior, and the self-referential component of episodic memory in humans is mediated by the corollary discharge.
...
1
2
...

References

SHOWING 1-10 OF 57 REFERENCES
The effects of hippocampal and cortical lesions on single-alternation go, no-go acquisition in rats
TLDR
Rats with hippocampal ablations, those with cortical control lesions, and normals were trained on a go/no-go single-alternation task in an operant situation and no group differences were found in utilization of the SD.
Medial septal lesions disrupt spatial, but not nonspatial, working memory in rats.
TLDR
The results indicate that damage to the septohippocampal system disrupts spatial working memory more than it disrupts nonspatial working memory.
Hippocampal Lesions Attenuate Latent Inhibition and the Decline of the Orienting Response in Rats
  • H. Kaye, J. Pearce
  • Psychology, Biology
    The Quarterly journal of experimental psychology. B, Comparative and physiological psychology
  • 1987
TLDR
H hippocampal lesions influence both the loss of associability of a stimulus and the decline in the OR it elicits, which suggests that the OR acts as an index of stimulus associability.
Medial temporal lesions in monkeys impair memory on a variety of tasks sensitive to human amnesia.
TLDR
The results of the present study strengthen the conclusion that monkeys with medial temporal lesions constitute an animal model of human amnesia.
Preserved configural learning and spatial learning impairment in rats with hippocampal damage
TLDR
The results demonstrate that a spatial learning deficit in rats with hippocampal damage does not necessarily occur in the setting of a general configural learning impairment, as originally suggested by Sutherland and Rudy (1989).
Double dissociation of fornix and caudate nucleus lesions on acquisition of two water maze tasks: further evidence for multiple memory systems.
TLDR
The double dissociation observed supports the hypothesis that the hippocampus and caudate nucleus are parts of systems that differ in the type of memory they mediate.
...
1
2
3
4
5
...