Effects of medetomidine on hepatic EROD activity in three species of fish.

@article{Lennquist2008EffectsOM,
  title={Effects of medetomidine on hepatic EROD activity in three species of fish.},
  author={Anna Lennquist and Malin C. Celander and Lars F{\"o}rlin},
  journal={Ecotoxicology and environmental safety},
  year={2008},
  volume={69 1},
  pages={
          74-9
        }
}
Medetomidine, an antifouling candidate, was investigated for its effects on cytochrome P4501A (CYP1A) activity in fish. Rainbow trout (Oncorhynchus mykiss), turbot (Psetta maxima), and Atlantic cod (Gadus morhua) were exposed to medetomidine either via i.p. injection (<5 micromol (1mg)/kg) or via water (<50 nM). Enzyme activity was measured as ethoxyresorufin-O-deethylase (EROD) activity in liver microsomes. There was a small (2-7-fold) increase in EROD activity in rainbow trout. In turbot… CONTINUE READING
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