Effects of mechanical stress and carvedilol in lamin A/C-deficient dilated cardiomyopathy.

@article{Chandar2010EffectsOM,
  title={Effects of mechanical stress and carvedilol in lamin A/C-deficient dilated cardiomyopathy.},
  author={Suchitra Chandar and Li Sze Yeo and Christiana Leimena and Ju-Chiat Tan and Xiao-Hui Xiao and Vesna Nikolova-Krstevski and Yoshinori Yasuoka and Margaret Gardiner-Garden and Jianxin Wu and Scott H. Kesteven and Lina Karlsdotter and Shweta Natarajan and Arthur Carlton and Stephen P. Rainer and Michael P. Feneley and Diane Fatkin},
  journal={Circulation research},
  year={2010},
  volume={106 3},
  pages={573-82}
}
RATIONALE Mutations in the LMNA gene, which encodes the nuclear lamina proteins lamin A and lamin C, are the most common cause of familial dilated cardiomyopathy (DCM). Mechanical stress-induced apoptosis has been proposed as the mechanism underpinning DCM in lamin A/C-deficient hearts, but supporting in vivo evidence has been lacking. OBJECTIVE Our aim was to study interventions to modify mechanical stress in heterozygous Lmna knockout (Lmna(+/-)) mice. METHODS AND RESULTS Cardiac… CONTINUE READING