Effects of mechanical loading on the tissues of the rabbit knee.

@article{Radin1984EffectsOM,
  title={Effects of mechanical loading on the tissues of the rabbit knee.},
  author={Eric L. Radin and R. Bruce Martin and David B. Burr and Bruce Caterson and Robert D H Boyd and Charles Goodwin},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={1984},
  volume={2 3},
  pages={221-34}
}
We studied changes in subchondral bone and articular cartilage in an animal model of osteoarthrosis. In this model we applied repetitive impulsive loads to rabbits' knees. Their legs were held in short leg splints so the rabbits were unable to dampen the peak applied load with ankle flexion. After sacrifice, at 1 day to 6 weeks, we studied proximal tibial load-bearing cartilage histologically, biochemically, and with radioactive sulfate uptake. We also studied the subchondral bone under that… CONTINUE READING
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