Effects of mechanical forces on signal transduction and gene expression in endothelial cells.

@article{Chien1998EffectsOM,
  title={Effects of mechanical forces on signal transduction and gene expression in endothelial cells.},
  author={Sandy Sandy Chien and Shu-hong Li and Yeun Jund Shyy},
  journal={Hypertension},
  year={1998},
  volume={31 1 Pt 2},
  pages={
          162-9
        }
}
Fluid shear stress and circumferential stretch play important roles in maintaining the homeostasis of the blood vessel, and they can also be pathophysiological factors in cardiovascular diseases such as atherosclerosis and hypertension. The uses of flow channels and stretch devices as in vitro models have helped to elucidate the mechanisms of signal transduction and gene expression in cultured endothelial cells in response to shear stress, which is a function of blood flow and vascular geometry… CONTINUE READING

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