Effects of mechanical forces on maintenance and adaptation of form in trabecular bone

@article{Huiskes2000EffectsOM,
  title={Effects of mechanical forces on maintenance and adaptation of form in trabecular bone},
  author={Rik Huiskes and R Ronald Ruimerman and G. Harry van Lenthe and J. D. Janssen},
  journal={Nature},
  year={2000},
  volume={405},
  pages={704-706}
}
The architecture of trabecular bone, the porous bone found in the spine and at articulating joints, provides the requirements for optimal load transfer, by pairing suitable strength and stiffness to minimal weight according to rules of mathematical design. But, as it is unlikely that the architecture is fully pre-programmed in the genes, how are the bone cells informed about these rules, which so obviously dictate architecture? A relationship exists between bone architecture and mechanical… 
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