Effects of mechanical flexion on the penetration of fullerene amino acid-derivatized peptide nanoparticles through skin.

@article{Rouse2007EffectsOM,
  title={Effects of mechanical flexion on the penetration of fullerene amino acid-derivatized peptide nanoparticles through skin.},
  author={Jillian G. Rouse and Jianzhong Yang and Jessica P. Ryman-Rasmussen and Andrew R Barron and Nancy A Monteiro-Riviere},
  journal={Nano letters},
  year={2007},
  volume={7 1},
  pages={155-60}
}
Dermatomed porcine skin was fixed to a flexing device and topically dosed with 33.5 mg.mL-1 of an aqueous solution of a fullerene-substituted phenylalanine (Baa) derivative of a nuclear localization peptide sequence (Baa-Lys(FITC)-NLS). Skin was flexed for 60 or 90 min or left unflexed (control). Confocal microscopy depicted dermal penetration of the nanoparticles at 8 h in skin flexed for 60 and 90 min, whereas Baa-Lys(FITC)-NLS did not penetrate into the dermis of unflexed skin until 24 h… CONTINUE READING

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