Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia.

@article{Asahi2001EffectsOM,
  title={Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia.},
  author={Minoru Asahi and Xiaohai Wang and Tetsuji Mori and Toshihisa Sumii and Jae Chang Jung and Michael A. Moskowitz and Mary Elizabeth Fini and Eng H. Lo},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 19},
  pages={7724-32}
}
Deleterious processes of extracellular proteolysis may contribute to the progression of tissue damage after acute brain injury. We recently showed that matrix metalloproteinase-9 (MMP-9) knock-out mice were protected against ischemic and traumatic brain injury. In this study, we examined the mechanisms involved by focusing on relevant MMP-9 substrates in blood-brain barrier, matrix, and white matter. MMP-9 knock-out and wild-type mice were subjected to transient focal ischemia. MMP-9 levels… CONTINUE READING
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Extracellular proteolysis and brain injury

  • ML Cuzner, EH Lo
  • Neuroprotection (Lo EH, Marwah J, eds…
  • 2001
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