Effects of matrix elasticity and cell density on human mesenchymal stem cells differentiation.

@article{Xue2013EffectsOM,
  title={Effects of matrix elasticity and cell density on human mesenchymal stem cells differentiation.},
  author={Ruyue Xue and Julie Yi-shuan Li and Yiting Yeh and Li Yang and Shu Chien},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2013},
  volume={31 9},
  pages={1360-5}
}
Human mesenchymal stem cells (hMSCs) can differentiate into various cell types, including osteogenic and chondrogenic cells. The matrix elasticity and cell seeding density are important factors in hMSCs differentiation. We cultured hMSCs at different seeding densities on polyacrylamide hydrogels with different stiffness corresponding to Young's moduli of 1.6 ± 0.3 and 40 ± 3.6 kPa. The promotion of osteogenic marker expression by hard gel is overridden by a high seeding density. Cell seeding… CONTINUE READING
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