Effects of maternal separation on neuropeptide Y and calcitonin gene-related peptide in "depressed" Flinders Sensitive Line rats: a study of gene-environment interactions.

@article{Wrtwein2006EffectsOM,
  title={Effects of maternal separation on neuropeptide Y and calcitonin gene-related peptide in "depressed" Flinders Sensitive Line rats: a study of gene-environment interactions.},
  author={Gitta W{\"o}rtwein and Henriette Husum and Weronica Andersson and Tom Gert Bolwig and Aleksander A. Math{\'e}},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2006},
  volume={30 4},
  pages={684-93}
}
Interactions between genetic vulnerability to stress/depression and early life experience may play a crucial role in the pathogenesis of mood disorders. Here we explore this hypothesis by superimposing early life trauma in the form of maternal deprivation for 180 min per day from postnatal day 2 to 14 onto a genetic model of depression/susceptibility to… CONTINUE READING