Effects of maternal high-fat diet on serum lipid concentration and expression of peroxisomal proliferator-activated receptors in the early life of rat offspring.

@article{Yamaguchi2010EffectsOM,
  title={Effects of maternal high-fat diet on serum lipid concentration and expression of peroxisomal proliferator-activated receptors in the early life of rat offspring.},
  author={Rie Shigetomi Yamaguchi and Yoshimi Nakagawa and Y-J Liu and Yasuko Fujisawa and Syuuitu Sai and Eiko Nagata and Shinichiro Sano and Eiichiro Satake and Reiko Matsushita and Takako Nakanishi and Karen E. Chapman and Jonathan R Seckl and Takehiko Ohzeki},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  year={2010},
  volume={42 11},
  pages={821-5}
}
Peroxisomal proliferator-activated receptors (PPARs) play an important role in the regulation of lipid metabolism. The aim of this study was to investigate the effects of a maternal high-fat (HF) diet on serum lipid concentration and PPAR gene expression in liver and adipose tissue in the early life of the rat offspring. Female Sprague-Dawley rats were fed either an HF or control (CON) diet 6 weeks before mating and throughout gestation and lactation. Blood and tissue samplings of male… CONTINUE READING