Effects of manidipine and other calcium antagonists on rat renal arcuate arteries.

  title={Effects of manidipine and other calcium antagonists on rat renal arcuate arteries.},
  author={Martin Pfaffendorf and M-J. Mathy and Pieter A. van Zwieten},
  journal={American heart journal},
  volume={125 2 Pt 2},
We investigated the effect of 1,4-dihydropyridine calcium antagonists (nifedipine, nisoldipine, and manidipine) on serotonin (5-hydroxytryptamine [5-HT])- and KCl (120 mmol/L)-induced contractions of rat isolated renal arcuate arteries. The preparation showed the well-known biphasic response to KCl-induced depolarization. All three calcium antagonists were more potent in inhibiting the second phase (tonic) compared with the first phase (transient) of the effect. The inhibitory concentration of… 
Role of manidipine in the management of patients with hypertension
In elderly patients with mild-to-moderate essential hypertension, manidipine is able to significantly decrease blood pressure compared with placebo for up to 3 years of treatment, and is well-tolerated with few untoward adverse effects related to vasodilation.
Manidipine: a review of its use in hypertension.
Manidipine has shown antihypertensive efficacy and appears to be well tolerated in adult and elderly patients with mild or moderate essential hypertension and type 2 diabetes mellitus in randomised, long term comparative trials.
Regulation of renal artery smooth muscle tone by α1-adrenoceptors: role of voltage-gated calcium channels and intracellular calcium stores
The results suggest a key role of voltage-dependent Ca2+ channels and intracellular Ca2-sensitive stores in the α1A-adrenoceptor induced contraction of the renal artery.
Metabolic Effects of Manidipine
Ongoing research is expected to clarify further the action of these agents at the cellular level and to assist with the optimization of antihypertensive therapy, particularly in patients with elevated cardiovascular risk profiles.
Nisoldipine Coat-Core
It appears that reflex sympathetic stimulation is attenuated by the consistent plasma drug concentrations and blood pressure-lowering effects achieved with the nisoldipine coat-core formulation, a useful alternative to other antihypertensive agents in the management of patients with hypertension.


Effects of a new dihydropyridine derivative, CV-4093.2HCl, on renal hemodynamics in spontaneously hypertensive rats.
The results suggest that CV-4093.2HCl has a relatively higher affinity for the renal vascular bed (renal resistance vessels), and its effect on renal hemodynamics seems to be beneficial for treating hypertension.
The Selective Inhibition of Serotonin‐ Induced Contractions of Rabbit Cerebral Vascular Smooth Muscle by Calcium‐ Antagonistic Dihydropyridines: An Investigation of the Mechanism of Action of Nimodipine
  • R. Towart
  • Chemistry, Medicine
    Circulation research
  • 1981
It is postulated that the selective inhibition of the sustained tonic contraction of the basilar artery is due to a selective inhibition by nimodipine of calcium movement through ROCs in this vessel.
Constrictive Effect of Serotonin on Visible Renal Arteries: A Pharmacoangiographic Study in Anesthetized Dogs
It is suggested that 5HT constricts visible renal arteries via interaction with the 5HT-2 receptor, and that this in vivo effect is modified by arterial synthesis of vasodilator prostaglandins in the anesthetized dog.
Diverse Vascular Responses to Serotonin in the Conscious Rabbit: Effects of Serotonin Antagonists on Renal Artery Spasm
Vascular conductance in the mesenteric, hindquarter, and renal beds of the conscious rabbit was derived from regional blood flow (pulsed Doppler flowmeter) and ear artery pressure, and it is suggested that 5-HT2 receptors mediate the contraction of the renal artery, but that “5-HT1-like” receptors mediated the dilatation in the renal, mesEnteric, and hindquarter beds in theconscious rabbit.
Interaction of the antihypertensive drug felodipine with calmodulin
Felodipine is a new antihypertensive agent which seems specifically to dilate precapillary resistance vessels in vivo and is a structural analogue of nifedipine1 and SKF 242602, implying that their vascular as well as myocardial actions are due to a blockade of Ca2+ influx.
Comparison of the Inhibitory Effects of Nifedipine and Nimodipine on Mechanical Responses of Isolated Rat Coronary Small Arteries
Both nifedipine and nimodipine are potent and effective vasodilators, having similar actions on the spontaneous myogenic tone and serotonin-induced responses in the rat coronary resistance arteries, but nimmodipine is more potent and more effective than nifingipine in inhibiting potassium- induced responses.
Role of prostanoids in the increased vascular responsiveness and delayed tachyphylaxis to serotonin in the kidney of spontaneously hypertensive rats.
The isolated and perfused kidney of the spontaneously hypertensive rat (SHR) exhibits an increased vascular reactivity and a delayed tachyphylaxis to serotonin when compared with normotensive Wistar-Kyoto (WKY) rats.
Comparison of Nifedipine and Nisoldipine on Human Arteries and Human Cardiac Tissues In Vitro
Nisoldipine was twenty times more potent than nifedipine as an inhibitor of increase in tone induced by depolarization (100 mM K+) and the rhythmic activity induced by serotonin (10μM) was more sensitive to nis oldipine than to nifingipine.
A comparison of the inhibitory effect of cinnarizine and papaverine on the noradrenaline- and calcium-evoked contraction of isolated rabbit aorta and mesenteric arteries.
Results suggest that cinnarizine and papaverine antagonize vascular contraction by different mechanisms, and cinnARizine seems to act by reducing membrane permeability to extracellular calcium.
5-Hydroxytryptamine does not release endothelium-derived relaxing factor in rat isolated coronary arteries.
It is concluded that rat coronary artery endothelium is unresponsive to 5- HT because it lacks 5-HT1 receptors.