Effects of manidipine and other calcium antagonists on rat renal arcuate arteries.

@article{Pfaffendorf1993EffectsOM,
  title={Effects of manidipine and other calcium antagonists on rat renal arcuate arteries.},
  author={Martin Pfaffendorf and M-J. Mathy and Pieter A. van Zwieten},
  journal={American heart journal},
  year={1993},
  volume={125 2 Pt 2},
  pages={
          571-7
        }
}
We investigated the effect of 1,4-dihydropyridine calcium antagonists (nifedipine, nisoldipine, and manidipine) on serotonin (5-hydroxytryptamine [5-HT])- and KCl (120 mmol/L)-induced contractions of rat isolated renal arcuate arteries. The preparation showed the well-known biphasic response to KCl-induced depolarization. All three calcium antagonists were more potent in inhibiting the second phase (tonic) compared with the first phase (transient) of the effect. The inhibitory concentration of… 
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