Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus.

@article{Sumanont2007EffectsOM,
  title={Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus.},
  author={Yaowared Sumanont and Yukihisa Murakami and Michihisa Tohda and Opa Vajragupta and Hiroshi Watanabe and Kinzo Matsumoto},
  journal={Biological & pharmaceutical bulletin},
  year={2007},
  volume={30 9},
  pages={1732-9}
}
This study aimed to investigate the mechanism underlying the protective effects of manganese complexes of curcumin (Cp-Mn) and diacetylcurcumin (DiAc-Cp-Mn) on kainic acid (KA)-induced excitotoxicity in the rat hippocampus. Systemic injection of KA (10 mg/kg, i.p.) caused seizures and increased the expression of neurotoxic markers, immediate early genes [c… CONTINUE READING