Effects of macromolecular crowding and DNA looping on gene regulation kinetics

@inproceedings{Li2009EffectsOM,
  title={Effects of macromolecular crowding and DNA looping on gene regulation kinetics},
  author={Gene-Wei Li and Otto G. Berg and Johan Elf},
  year={2009}
}
DNA-binding proteins control how genomes function. The theory of facilitated diffusion1 explains how DNA-binding proteins can find targets apparently faster than the diffusion limit by using reduced dimensionality2,3—combining threedimensional (3D) diffusion through cytoplasm with 1D sliding along DNA (refs 3–15). However, it does not include a description of macromolecular crowding on DNA as observed in living cells. Here, we show that such a physical constraint to sliding greatly reduces the… CONTINUE READING
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Facilitated target location in sequence-dependent potential

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