Effects of mGlu1 and mGlu5 receptor antagonists on negatively reinforced learning.

@article{Gravius2005EffectsOM,
  title={Effects of mGlu1 and mGlu5 receptor antagonists on negatively reinforced learning.},
  author={Andreas Gravius and Malgorzata Pietraszek and Daniela Schaefer and Werner H. Schmidt and Wojciech Danysz},
  journal={Behavioural pharmacology},
  year={2005},
  volume={16 2},
  pages={113-21}
}
Effects on aversive learning of the novel highly selective mGlu5 receptor antagonist [(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) and mGlu1 receptor antagonist (3-ethyl-2-methyl-quinolin-6-yl)-(4-methoxy-cyclohexyl)-methanone methanesulfonate (EMQMCM) were tested, after systemic administration, in the passive avoidance (PA) and fear potentiated startle (FPS) paradigms. Both MTEP at 10 mg/kg and EMQMCM at 5 and 10 mg/kg, given 30 min before training, impaired acquisition of the passive… CONTINUE READING

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