Effects of lysosomotropic agents, cytochalasin B and colchicine on the "down-regulation" of prolactin receptors in mammary gland explants.

Abstract

Effects of lysosomotropic agents and drugs which disrupt the cytoskeleton on prolactin receptor levels were studied in organ culture of rabbit mammary glands. As we have shown previously, prolactin is able to induce a down-regulation of its own receptor levels. In the present experiments, lysosomotropic agents, chloroquine, ammonium chloride and methylamine… (More)

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