Effects of lysosomal protease inhibitors on the degradation of acetylated low density lipoprotein in cultured rat peritoneal macrophages.

Abstract

The effect of protease inhibitors, leupeptin and pepstatin A, on the metabolism of acetylated low density lipoprotein (acetyl-LDL) was investigated in cultured rat peritoneal macrophages and compared with that of chloroquine. While both leupeptin and pepstatin inhibited the proteolytic degradation of 125I-acetyl-LDL, a combination of both showed an additive… (More)

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@article{Kuroda1994EffectsOL, title={Effects of lysosomal protease inhibitors on the degradation of acetylated low density lipoprotein in cultured rat peritoneal macrophages.}, author={T. Kuroda and Masao Yoshinari and K. Okamura and Katsuko Okazawa and Hiroko Ikenoue and K. Sato and M. Fujishima}, journal={Journal of atherosclerosis and thrombosis}, year={1994}, volume={1 1}, pages={41-4} }