Effects of lysine clonixinate and ketorolac tromethamine on prostanoid release from various rat organs incubated ex vivo.

@article{Pallapies1995EffectsOL,
  title={Effects of lysine clonixinate and ketorolac tromethamine on prostanoid release from various rat organs incubated ex vivo.},
  author={Dirk Pallapies and Andrew G. Salinger and Angela M Meyer zum Gottesberge and Debra J Atkins and G. Rohleder and P. Nagyiv{\'a}nyi and Bernhard A. Peskar},
  journal={Life sciences},
  year={1995},
  volume={57 2},
  pages={83-9}
}
The release of prostanoids from rat brain, gastric mucosa, lungs and kidneys incubated ex vivo has been investigated for up to 5 h after oral administration of 10 mg/kg lysine clonixinate or 1 mg/kg ketorolac tromethamine. Additionally, 60 min after drug administration, a time point of near-maximal inhibition of prostanoid release, the effects of 2.5, 10 and 30 mg/kg lysine clonixinate and of 0.0225, 0.15 and 1 mg/kg ketorolac tromethamine were compared. In all organs investigated both drugs… CONTINUE READING
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