Effects of lycopene on the insulin-like growth factor (IGF) system in premenopausal breast cancer survivors and women at high familial breast cancer risk.

@article{Voskuil2008EffectsOL,
  title={Effects of lycopene on the insulin-like growth factor (IGF) system in premenopausal breast cancer survivors and women at high familial breast cancer risk.},
  author={Dorien W. Voskuil and Alina Vrieling and C M Korse and Jos H. Beijnen and Johannes M. G. M. Bonfrer and Jaap van Doorn and Reinie Kaas and Hester Sa Oldenburg and Nicola S. Russell and Emiel J. Th Rutgers and Senno Verhoef and Flora E van Leeuwen and Laura van't Veer and Matti A. Rookus},
  journal={Nutrition and cancer},
  year={2008},
  volume={60 3},
  pages={342-53}
}
Insulin-like growth factor-I (IGF-I) is an important growth factor associated with increased risk of premenopausal breast cancer. We conducted a randomized, placebo-controlled, double-blind, crossover trial to evaluate whether tomato-derived lycopene supplementation (30 mg/day for 2 mo) decreases serum levels of total IGF-I in premenopausal women with 1) a history of breast cancer (n=24) or 2) a high familial breast cancer risk (n=36). Also, IGF binding protein (IGFBP) increasing effects were… CONTINUE READING
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