Effects of low and high doses of selective sigma ligands: further evidence suggesting the existence of different subtypes of sigma receptors

@article{Bergeron1997EffectsOL,
  title={Effects of low and high doses of selective sigma ligands: further evidence suggesting the existence of different subtypes of sigma receptors},
  author={Richard Bergeron and Guy Debonnel},
  journal={Psychopharmacology},
  year={1997},
  volume={129},
  pages={215-224}
}
Several high affinity sigma (σ) ligands, such as DTG, JO-1784, (+)-pentazocine, BD-737 and L-687,384, administered at low doses act as agonists by potentiating N-methyl-d-aspartate (NMDA)-induced activation of pyramidal neurons in the CA3 region of the rat dorsal hippocampus. This potentiation is dose-dependent at doses between 1 and 1000 µg/kg, IV but bell-shaped dose-response curves are obtained. Other σ ligands like haloperidol, BMY-14802, (+)3-PPP and NE-100 administered at low doses act as… CONTINUE READING

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