Effects of lovastatin on breast cancer cells: a proteo-metabonomic study

Abstract

Statins are cholesterol-lowering drugs with pleiotropic activities including inhibition of isoprenylation and reduction of signals driving cell proliferation and survival responses. In this study we evaluated the effects of lovastatin acid and lactone on breast cancer MDAMB231 and MDAMB468 cells using a combination of proteomic and metabonomic profiling… (More)
DOI: 10.1186/bcr2485

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