Effects of lovastatin (mevinolin) on sterol levels and on activity of azoles in Saccharomyces cerevisiae.

@article{Lorenz1990EffectsOL,
  title={Effects of lovastatin (mevinolin) on sterol levels and on activity of azoles in Saccharomyces cerevisiae.},
  author={R. Lorenz and L. Parks},
  journal={Antimicrobial Agents and Chemotherapy},
  year={1990},
  volume={34},
  pages={1660 - 1665}
}
  • R. Lorenz, L. Parks
  • Published 1990
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • The hypocholesterolemic drug lovastatin (mevinolin) was found to be very effective in lowering the sterol levels of the wild-type yeast Saccharomyces cerevisiae. Lovastatin dramatically decreased the steryl ester content from 2.62 to 0.8 micrograms/mg (dry weight), whereas the free sterol content decreased only from 2.79 to 2.24 micrograms/mg (dry weight) when lovastatin was present in the medium at 10 micrograms/ml. At higher concentrations (100 micrograms/ml), lovastatin nearly abolished the… CONTINUE READING
    89 Citations

    Figures, Tables, and Topics from this paper

    Depletion of the Squalene Synthase (ERG9) Gene Does Not Impair Growth of Candida glabrata in Mice
    • 49
    • PDF
    Atorvastatin-induced cell toxicity in yeast is linked to disruption of protein isoprenylation.
    • 13
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 37 REFERENCES
    Characteristics of sterol uptake in Saccharomyces cerevisiae.
    • 48
    • PDF
    Inhibition of sterol biosynthesis by ergosterol and cholesterol in Saccharomyces cerevisiae.
    • 22
    In vivo effects of fenpropimorph on the yeast Saccharomyces cerevisiae and determination of the molecular basis of the antifungal property.
    • 100
    • PDF
    Regulation of ergosterol biosynthesis and sterol uptake in a sterol-auxotrophic yeast.
    • 25
    • PDF
    Effect of unsaturated fatty acids on sterol biosynthesis in yeast.
    • 10
    An assessment of the specificity of sterol uptake and esterification in Saccharomyces cerevisiae.
    • 47
    Isolation and characterization of mevinolin resistant mutants of Saccharomyces cerevisiae.
    • 13
    Metabolic interconversion of free sterols and steryl esters in Saccharomyces cerevisiae.
    • 87
    • PDF
    Correlation of inhibition of sterol synthesis with growth-inhibitory action of imidazole antimycotics in Candida albicans.
    • 12