Effects of lovastatin (mevinolin) on sterol levels and on activity of azoles in Saccharomyces cerevisiae.

  title={Effects of lovastatin (mevinolin) on sterol levels and on activity of azoles in Saccharomyces cerevisiae.},
  author={R. Lorenz and L. Parks},
  journal={Antimicrobial Agents and Chemotherapy},
  pages={1660 - 1665}
  • R. Lorenz, L. Parks
  • Published 1990
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • The hypocholesterolemic drug lovastatin (mevinolin) was found to be very effective in lowering the sterol levels of the wild-type yeast Saccharomyces cerevisiae. Lovastatin dramatically decreased the steryl ester content from 2.62 to 0.8 micrograms/mg (dry weight), whereas the free sterol content decreased only from 2.79 to 2.24 micrograms/mg (dry weight) when lovastatin was present in the medium at 10 micrograms/ml. At higher concentrations (100 micrograms/ml), lovastatin nearly abolished the… CONTINUE READING
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