Effects of losartan, a nonpeptide angiotensin II receptor antagonist, on cardiac hypertrophy and the tissue angiotensin II content in spontaneously hypertensive rats.

@article{Mizuno1992EffectsOL,
  title={Effects of losartan, a nonpeptide angiotensin II receptor antagonist, on cardiac hypertrophy and the tissue angiotensin II content in spontaneously hypertensive rats.},
  author={Kyoichi Mizuno and Momo Tani and Shinji Hashimoto and Susumu Niimura and Hiroo Sanada and Hiroshi Watanabe and Masahiko Ohtsuki and Sōtarō Fukuchi},
  journal={Life sciences},
  year={1992},
  volume={51 5},
  pages={
          367-74
        }
}
Losartan, a recently developed nonpeptide angiotensin II (Ang II) receptor antagonist, was administered orally to 10-week-old spontaneously hypertensive rats (SHR) for 2 weeks. Cardiac weight and tissue Ang II, as well as plasma renin activity (PRA) and Ang II, were determined. Treatment with Losartan (10 mg/kg per day) lowered blood pressure markedly. Losartan reduced significantly the left ventricular weight by 11% compared with control rats. The left ventricular Ang II content was lowered by… CONTINUE READING