Effects of lorazepam and its withdrawal on sleep, performance, and subjective state

@article{Walsh1983EffectsOL,
  title={Effects of lorazepam and its withdrawal on sleep, performance, and subjective state},
  author={J. Walsh and P. Schweitzer and S. Parwatikar},
  journal={Clinical Pharmacology & Therapeutics},
  year={1983},
  volume={34}
}
The effects of 3 mg lorazepam on polysomnographic recordings, performance, anxiety, and perceived sleep were examined. Six insomniac subjects slept in the sleep laboratory for 18 consecutive nights after having taken placebo or lorazepam. Polysomnographic data and subjective reports indicated hypnotic efficacy in terms of sleep initiation and maintenance. There was some evidence of rebound insomnia after drug withdrawal, although it was not evident from all measures. Clear performance… Expand
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  • 559
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  • 5
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  • 115
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References

SHOWING 1-10 OF 10 REFERENCES
Lorazepam—Efficacy, side effects, and rebound phenomena
  • 39
Rebound insomnia: a new clinical syndrome.
  • 196
Anxiety and sleep after fosazepam.
  • 28
Hypnotic efficacy of lorazepam and flurazepam
  • 12
Effects of benzodiazepines on sleep and wakefulness.
  • 32
The use of short- and long-acting hypnotics in clinical medicine.
  • A. Nicholson
  • Medicine
  • British journal of clinical pharmacology
  • 1981
  • 40
Clinical Pharmacokinetics of Oxazepam and Lorazepam
  • 187
Multiple Comparisons among Means
  • 2,873
  • PDF
Hypnotics: rebound insomnia and residual sequelae.
  • A. Nicholson
  • Medicine
  • British journal of clinical pharmacology
  • 1980
  • 31