Effects of loratadine on cytosolic Ca2+ levels and leukotriene release: novel mechanisms of action independent of the anti-histamine activity.

@article{Letari1994EffectsOL,
  title={Effects of loratadine on cytosolic Ca2+ levels and leukotriene release: novel mechanisms of action independent of the anti-histamine activity.},
  author={Ornella Letari and Antonio Miozzo and Giancarlo Folco and P. A. Belloni and Araceli Sala and Gianenrico Rovati and Simonetta Nicosia},
  journal={European journal of pharmacology},
  year={1994},
  volume={266 3},
  pages={
          219-27
        }
}
Loratadine, a non-sedating anti-histamine drug, displays in vitro potential anti-allergic properties not related to its interaction with the histamine H1 receptor. In a search for the mechanisms of these actions, we have found that loratadine induces an elevation of cytosolic calcium ion, [Ca2+]i, in rat peritoneal macrophages or human platelets. The mechanism of this elevation resides in the ability of loratadine to discharge intracellular Ca2+ stores, similarly to thapsigargin. This in turn… CONTINUE READING