Effects of loprazolam and of triazolam on psychological functions

  title={Effects of loprazolam and of triazolam on psychological functions},
  author={K. Morgan and Kirstine Adam and Ian Oswald},
Twelve poor sleepers of mean age 52 years performed 2 h of laboratory tests three times on 1 day during each week of nightly intake of loprazolam 0.5 mg, loprazolam 1 mg, triazolam 0.5 mg, or continued placebos. Only in the mornings did loprazolam 1 mg cause impairment in manual dexterity and card-sorting, and triazolam 0.5 mg in manual dexterity. Using difference from baseline, withdrawal of either drug after 3 weeks was associated with poorer subjective quality of sleep than following… 
Benzodiazepines and vigilance performance: a review
There is no evidence that benzodiazepines aggravate the vigilance decrement occurring under normal conditions, and it is unlikely that impairments in vigilance are simply a byproduct of global, sedative effects, but there is uncertainty regarding measures of general sedation.
Hypnotics in the Elderly
The need for greater circumspection in the choice and use of hypnotic drugs among elderly patients, and the need for a more broadly based clinical approach to the management of sleep problems in old age are emphasised.
Triazolam use in the dental setting: a report of 270 uses over 15 years.
It is indicated that triazolam may be an extremely effective medication when used for OCS in the dental realm and bears further investigation to confirm these positive results.


Effects of loprazolam and of triazolam on sleep and overnight urinary cortisol
Nine poor sleepers of mean age 61 years were studied while they took loprazolam 0.5 mg, lop Razolam 1 mg and triazolam 2 mg for 3-week periods and in the third week of use neither drug was associated with late-night wakefulness.
Early morning insomnia with rapidly eliminated benzodiazepines.
Early morning insomnia, a significant increase in wakefulness during the final hours of drug nights, occurred after 1 or 2 weeks of nightly administration of benzodiazepine hypnotics with short
Comparative pharmacokinetics of midazolam and loprazolam in healthy subjects after oral administration.
The pharmacokinetics of oral midazolam and loprazolam were studied in eight healthy young volunteers in a cross-over design and there was no significant correlation between the half-lives of the two drugs.
Anxiety caused by a short-life hypnotic
reports four deaths in 30 years attributed to milk-related infection as against a yearly toll of 150 000 deaths from coronary disease in England and Wales. The evidence which began to accumulate in
Effects of loprazolam
  • 1984
Towards a rational use of hypnotics
  • 1983
b) Comparative pharmacokinetics of midazolam and loprazolam in healthy ~ubjects after oral administration
  • Jochemsen R (ed) Clinical pharmacokinetics of benzodiazepine hypnotics. JH Pasmans BV
  • 1983
A preliminary investigation of the effects of a 1 , 4 benzodiazepine derivative ( HR 158 ) on subjective aspects of sleep and objective measures of early morning performance
  • Drugs Exp Clin Res
  • 1980
Pharmacokinetics of 5 benzodiazepine hypnotics in the same panel of healthy subjects