Effects of long-term theophylline treatment on adenosine A1-receptors in rat brain: autoradiographic evidence for increased receptor number and altered coupling to G-proteins.

@article{Fastbom1990EffectsOL,
  title={Effects of long-term theophylline treatment on adenosine A1-receptors in rat brain: autoradiographic evidence for increased receptor number and altered coupling to G-proteins.},
  author={Johan Fastbom and Bertil B. Fredholm},
  journal={Brain research},
  year={1990},
  volume={507 2},
  pages={195-9}
}
The effects of 2 weeks' treatment with theophylline (20 mg/kg i.p.) on the binding to adenosine A1-receptors was studied by autoradiography using the agonist [3H]N6-cyclohexyladenosine ([3H]CHA) and the antagonist [3H]8-cyclopentyl-1,3-dipropylxanthine ([3H]DPCPX) as ligands. A significant increase (10%) in [3H]CHA binding was measured only in the frontoparietal cortex. However, if the brain sections were incubated in the presence of 5 microM guanosine-5'-triphosphate (GTP), which by itself… CONTINUE READING

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