Effects of long-term storage on the detection of proteins, DNA, and mRNA in tissue microarray slides.

@article{Karlsson2011EffectsOL,
  title={Effects of long-term storage on the detection of proteins, DNA, and mRNA in tissue microarray slides.},
  author={Christina Elisabeth Karlsson and Mats G. Karlsson},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={2011},
  volume={59 12},
  pages={
          1113-21
        }
}
Storage of tissue slides has been claimed to induce dramatically reduced antigen detection particularly for immunohistochemistry (IHC). With tissue microarrays, the necessity to serially cut blocks in order to obtain as much material as possible is obvious. The presumed adverse effect of storage might hamper such an approach. The authors designed an experimental setting consisting of four different storage conditions with storage time of tissue slides of up to 1 year. Detection of proteins, DNA… CONTINUE READING

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