Effects of long-term primidone and phenytoin administration on canine hepatic function and morphology.

@article{Bunch1985EffectsOL,
  title={Effects of long-term primidone and phenytoin administration on canine hepatic function and morphology.},
  author={Susan E. Bunch and William L. Castleman and Betty H Baldwin and William E. Hornbuckle and Bud Christopher Tennant},
  journal={American journal of veterinary research},
  year={1985},
  volume={46 1},
  pages={105-15}
}
Primidone, phenytoin, or phenytoin and primidone in combination were given to healthy Beagle dogs for 6 months. Serum biochemical changes in dogs given primidone alone or phenytoin and primidone in combination for the entire 6-month test period included increased activities of alanine aminotransferase, alkaline phosphatase (AP), and gamma-glutamyltransferase, and decreased concentrations of albumin and cholesterol. Changes in dogs given phenytoin alone were limited to increased AP activity and… CONTINUE READING