Effects of long-term monotherapy with enalapril, metoprolol, and digoxin on the progression of left ventricular dysfunction and dilation in dogs with reduced ejection fraction.

@article{Sabbah1994EffectsOL,
  title={Effects of long-term monotherapy with enalapril, metoprolol, and digoxin on the progression of left ventricular dysfunction and dilation in dogs with reduced ejection fraction.},
  author={Hani N. Sabbah and Hisashi Shimoyama and Tatsuji Kono and Ramesh Chandra Gupta and Victor G. Sharov and Guillermo Scicli and T. Barry Levine and Sidney Goldstein},
  journal={Circulation},
  year={1994},
  volume={89 6},
  pages={2852-9}
}
BACKGROUND Recent clinical trials have suggested that therapy with angiotensin-converting enzyme inhibitors in asymptomatic patients with reduced left ventricular (LV) function can significantly reduce the incidence of congestive heart failure compared with patients receiving placebo. In the present study, we examined the effects of long-term monotherapy with enalapril, metoprolol, and digoxin on the progression of LV systolic dysfunction and LV chamber enlargement in dogs with reduced LV… CONTINUE READING

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