Effects of long-term estrogen treatment on IFN-gamma, IL-2 and IL-4 gene expression and protein synthesis in spleen and thymus of normal C57BL/6 mice.

@article{KarpuzogluSahin2001EffectsOL,
  title={Effects of long-term estrogen treatment on IFN-gamma, IL-2 and IL-4 gene expression and protein synthesis in spleen and thymus of normal C57BL/6 mice.},
  author={Ebru Karpuzoglu-Sahin and Yang Zhi-jun and Andrea J. Lengi and Nammalwar Sriranganathan and S. Ansar Ahmed},
  journal={Cytokine},
  year={2001},
  volume={14 4},
  pages={
          208-17
        }
}
Estrogens have been shown to markedly modulate the immune system. One mechanism by which estrogens could modulate the immune system is by regulating cytokines, an aspect not well-studied thus far. To address this issue, normal C57BL/6 orchiectomized mice were given estrogen and its effects on selected cytokines, interferon-gamma (IFN-gamma), interleukin 2 (IL-2) and IL-4 in lymphocytes from a developmental organ (thymus) and a mature lymphoid organ (spleen) examined. Estrogen significantly… CONTINUE READING

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