Effects of long-term electrical stimulation on some contractile and metabolic characteristics of fast rabbit muscles

  title={Effects of long-term electrical stimulation on some contractile and metabolic characteristics of fast rabbit muscles},
  author={Dirk Pette and Margaret E. Smith and Hans W. Staudte and Gerta Vrb{\'o}va},
  journal={Pfl{\"u}gers Archiv},
SummaryIntermittant long-term stimulation of fast rabbit muscles up to 28 days with a frequency pattern resembling that of a slow muscle (10 Imp/sec) led to a slowing of the time course of contraction already during the first week. There was an increase of tetanic tension as well. The observed rearrangement of activities of key enzymes of energy supplying metabolism was found to occur sequentially. Decreases of extramitochondrial enzymes of glycogenolysis (phosphorylase), glycolysis… 

Effects of different patterns of long-term stimulation on blood flow, fuel uptake and enzyme activities in rabbit fast skeletal muscles

Long-term electrical stimulation (14–28 days) of rabbit fast muscles (tibialis anterior, TA and extensor digitorum longus, EDL) using intermittent high frequency (3 trains per min of 5 s duration at

Influence of intermittent long-term stimulation on contractile, histochemical and metabolic properties of fibre populations in fast and slow rabbit muscles

A transformation of the fibre population under the influence of long-term intermittent stimulation is suggested, with a strong increase in mitochondria of all fibres and an increased resistance to fatigue.

Metabolite patterns related to exhaustion, recovery and transformation of chronically stimulated rabbit fast-twitch muscle

The results demonstrated an impressive capability of the muscle to recover with ongoing stimulation from an initial, dramatic disturbance in energy metabolism, and the depressed phosphorylation potential of the adenylate system may be an important signal triggering muscle fibre type transformation.

Enzyme activities of fatty acid oxidation and the respiratory chain in chronically stimulated fast-twitch muscle of the rabbit

The results indicate that the expression of the enzymes of the main metabolic systems of aerobic substrate oxidation, i.e. the citric acid cycle, the fatty acid oxidation and the respiratory chain, is regulated in a coordinate manner.

Biochemical and ultrastructural changes of skeletal muscle mitochondria after chronic electrical stimulation in rabbits

There is an excellent agreement between morphometric and biochemical measurements of tissue oxidative capacity between chronic electrical stimulation of tibialis anterior muscle in rabbits and qualitative changes within the mitochondrial population.

Fibre type specific transformations in the enzyme activity pattern of rat vastus lateralis muscle by prolonged endurance training

The results demonstrate a fundamental rearrangement of the energy metabolism of the muscle in response to prolonged, high intensity training and suggest that there might be no limit to the metabolic adaptability of skeletal muscle to increased contractile activity.

Effects of low-frequency electrical stimulation on fast and slow muscles of the rat

There may be a species difference regarding the readiness with which the transformation of fast to slow muscles can be brought about in rats, which show that slowing of contraction can be achieved by low-frequency activity of similar duration.

Relationships between early alterations in parvalbumins, sarcoplasmic reticulum and metabolic enzymes in chronically stimulated fast twitch muscle

It is suggested that an increase in free intracellular Ca2+ caused by increased contractile activity, which is then perpetuated by the decrease in Ca2-binding and sequestering capacities, might be the signal for such altered synthetic activities.

The effect of long-term stimulation of fast muscles on their blood flow, metabolism and ability to withstand fatigue

It is suggested that muscles chronically stimulated for 14–28 days use fats as the main source of energy during isometric contractions because of the predominantly oxidative metabolism facilitated by the higher density of capillaries.

Changes of energy metabolism, myosin light chain composition, lactate dehydrogenase isozyme pattern and fibre type distribution of denervated fast-twitch muscle from rabbit after low frequency stimulation

Prolonged direct stimulation of denervated muscle resulted in higher oxidative enzyme activities and glycolytic enzymes were decreased in activity and the LDH-isozyme pattern also shifted towards heart type.



Metabolic differentiation of rabbit skeletal muscle as induced by specific innervation.

The alterations show that a conversion of the metabolic type from “slow” to “fast” takes place and indicate a specific influence of the innervation on metabolic differentiation in muscle, that is the control of a specific pattern of enzyme synthesis.

Thyroid hormone induced changes in the enzyme activity pattern of energy-supplying metabolism of fast (white), slow (red), and heart muscle of the rat.

The increased activities of hexokinase in the skeletal muscles and of glycerophosphate dehydrogenase in red and heart muscle are interpreted as a coordinate process of a “long-term metabolic regulation” which is related to an elvelatd aerobic carbohydrate catabolism of muscle tissue and to an enhanced rate of basal metabolism.

Evaluation of the isolated perfused rat hindquarter for the study of muscle metabolism.

The results indicate that the isolated perfused hindquarter is a useful tool for studying muscle metabolism and suggest that ketone bodies, if present in sufficient concentration, are the preferred oxidative fuel of resting muscle.

Metabolic differentiation of distinct muscle types at the level of enzymatic organization.

Nature of the fuel, type of metabolism and catabolic rate thus represent fundamental elements in metabolic differentiation.

Interactions between motoneurones and muscles in respect of the characteristic speeds of their responses

An analytic investigation into the influence of nerve on muscle has been accomplished by dividing and cross-uniting nerves to fast and slow muscles, so that motoneurones formerly innervating the fast muscle come to innervate the slow muscle by virtue of the regenerative outgrowth of their fibres.

The influence of activity on some contractile characteristics of mammalian fast and slow muscles

1. The time course of contraction and relaxation in the isometric twitch of a rabbit soleus muscle becomes more rapid following tenotomy and spinal cord section. This increase in speed could be

A kinetic study of glycolytic enzyme synthesis in yeast.

  • P. MaitraZ. Lobo
  • Biology, Computer Science
    The Journal of biological chemistry
  • 1971

The Concurrent Regulation of Metabolically Related Enzymes

Comparisons of the repressed levels of isocitrate lyase and malate synthase on sucrose medium and the derepressed levels in acetate medium showed an over-all coordination between the levels of these two enzymes, suggesting that this type of coordination results from the metabolic repressors of each enzyme being in equilibrium or in a constant ratio to one another.