Effects of long-term electrical stimulation on some contractile and metabolic characteristics of fast rabbit muscles

@article{Pette2004EffectsOL,
  title={Effects of long-term electrical stimulation on some contractile and metabolic characteristics of fast rabbit muscles},
  author={Dirk Pette and Margaret E. Smith and Hans W. Staudte and Gerta Vrb{\'o}va},
  journal={Pfl{\"u}gers Archiv},
  year={2004},
  volume={338},
  pages={257-272}
}
SummaryIntermittant long-term stimulation of fast rabbit muscles up to 28 days with a frequency pattern resembling that of a slow muscle (10 Imp/sec) led to a slowing of the time course of contraction already during the first week. There was an increase of tetanic tension as well. The observed rearrangement of activities of key enzymes of energy supplying metabolism was found to occur sequentially. Decreases of extramitochondrial enzymes of glycogenolysis (phosphorylase), glycolysis… 

Effects of different patterns of long-term stimulation on blood flow, fuel uptake and enzyme activities in rabbit fast skeletal muscles

Long-term electrical stimulation (14–28 days) of rabbit fast muscles (tibialis anterior, TA and extensor digitorum longus, EDL) using intermittent high frequency (3 trains per min of 5 s duration at

Influence of intermittent long-term stimulation on contractile, histochemical and metabolic properties of fibre populations in fast and slow rabbit muscles

A transformation of the fibre population under the influence of long-term intermittent stimulation is suggested, with a strong increase in mitochondria of all fibres and an increased resistance to fatigue.

Metabolite patterns related to exhaustion, recovery and transformation of chronically stimulated rabbit fast-twitch muscle

The results demonstrated an impressive capability of the muscle to recover with ongoing stimulation from an initial, dramatic disturbance in energy metabolism, and the depressed phosphorylation potential of the adenylate system may be an important signal triggering muscle fibre type transformation.

Enzyme activities of fatty acid oxidation and the respiratory chain in chronically stimulated fast-twitch muscle of the rabbit

The results indicate that the expression of the enzymes of the main metabolic systems of aerobic substrate oxidation, i.e. the citric acid cycle, the fatty acid oxidation and the respiratory chain, is regulated in a coordinate manner.

Biochemical and ultrastructural changes of skeletal muscle mitochondria after chronic electrical stimulation in rabbits

There is an excellent agreement between morphometric and biochemical measurements of tissue oxidative capacity between chronic electrical stimulation of tibialis anterior muscle in rabbits and qualitative changes within the mitochondrial population.

Fibre type specific transformations in the enzyme activity pattern of rat vastus lateralis muscle by prolonged endurance training

The results demonstrate a fundamental rearrangement of the energy metabolism of the muscle in response to prolonged, high intensity training and suggest that there might be no limit to the metabolic adaptability of skeletal muscle to increased contractile activity.

Effects of low-frequency electrical stimulation on fast and slow muscles of the rat

There may be a species difference regarding the readiness with which the transformation of fast to slow muscles can be brought about in rats, which show that slowing of contraction can be achieved by low-frequency activity of similar duration.

Relationships between early alterations in parvalbumins, sarcoplasmic reticulum and metabolic enzymes in chronically stimulated fast twitch muscle

It is suggested that an increase in free intracellular Ca2+ caused by increased contractile activity, which is then perpetuated by the decrease in Ca2-binding and sequestering capacities, might be the signal for such altered synthetic activities.

The effect of long-term stimulation of fast muscles on their blood flow, metabolism and ability to withstand fatigue

It is suggested that muscles chronically stimulated for 14–28 days use fats as the main source of energy during isometric contractions because of the predominantly oxidative metabolism facilitated by the higher density of capillaries.

Changes of energy metabolism, myosin light chain composition, lactate dehydrogenase isozyme pattern and fibre type distribution of denervated fast-twitch muscle from rabbit after low frequency stimulation

Prolonged direct stimulation of denervated muscle resulted in higher oxidative enzyme activities and glycolytic enzymes were decreased in activity and the LDH-isozyme pattern also shifted towards heart type.
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