• DOI:10.2460/JAVMA.2002.221.654
• Corpus ID: 11617609

Effects of long-term administration of enalapril on clinical indicators of renal function in dogs with compensated mitral regurgitation.

@article{Atkins2002EffectsOL,
  title={Effects of long-term administration of enalapril on clinical indicators of renal function in dogs with compensated mitral regurgitation.},
  author={Clarke E Atkins and William A. Brown and Julie R Coats and Mary Ann Crawford and Teresa C DeFrancesco and Joel Edwards and Philip R Fox and Bruce W Keene and Linda B. Lehmkuhl and M.W. Luethy and Kathryn M. Meurs and J Petrie and Frank S. Pipers and Steven L. Rosenthal and Jennifer A Sidley and J Straus},
  journal={Journal of the American Veterinary Medical Association},
  year={2002},
  volume={221 5},
  pages={
          654-8
        }
}

• C. Atkins, W. A. Brown, +13 authors J. Straus
• Published 1 September 2002
• Medicine
• Journal of the American Veterinary Medical Association

OBJECTIVE
To determine the effect of long-term administration of enalapril on renal function in dogs with severe, compensated mitral regurgitation.

DESIGN
Randomized controlled trial.

ANIMALS
139 dogs with mitral regurgitation but without overt signs of heart failure.

PROCEDURE
Dogs were randomly assigned to be treated with enalapril (0.5 mg/kg [0.23 mg/lb], PO, q 24 h) or placebo, and serum creatinine and urea nitrogen concentrations were measured at regular intervals for up to 26 months.

RESULTS
Adequate information on renal function was obtained from 132 dogs; follow-up time ranged from 0.5 to 26 months (median, 12 months). Mean serum creatinine and urea nitrogen concentrations were not significantly different between dogs receiving enalapril and dogs receiving the placebo at any time, nor were concentrations significantly different from baseline concentrations. Proportions of dogs that developed azotemia or that had a +/- 35% increase in serum creatinine or urea nitrogen concentration were also not significantly different between groups.

CONCLUSIONS
And Clinical Relevance: Results suggest that administration of enalapril for up to 2 years did not have any demonstrable adverse effects on renal function in dogs with severe, compensated mitral regurgitation.