Effects of long-term active immunization with the second extracellular loop of human β1- or β3-adrenoceptors in thoracic aorta and mesenteric arteries in Lewis rats.

@article{Montaudon2016EffectsOL,
  title={Effects of long-term active immunization with the second extracellular loop of human β1- or β3-adrenoceptors in thoracic aorta and mesenteric arteries in Lewis rats.},
  author={E Montaudon and Laurence Dubreil and Val{\'e}rie Lalanne and Beno{\^i}t Jagu and Gilles Toumaniantz and Chantal Thorin and Daniel Henrion and J-C Desfontis and Lionel Martignat and Mohamed Yassine Mallem},
  journal={Vascular pharmacology},
  year={2016},
  volume={87},
  pages={129-138}
}
OBJECTIVE To evaluate whether active immunization producing β1- or β3-antibodies (β1-ABs and β3-ABs) detected in sera of patients with dilated cardiomyopathies has deleterious effects on vascular reactivity in Lewis rat thoracic aorta (TA) and small mesenteric arteries (SMA). DESIGN AND METHOD Lewis rats were immunized for 6months with peptidic sequences… CONTINUE READING