Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes.

@article{Kang1994EffectsOL,
  title={Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes.},
  author={Jing Kang and Alexander Leaf},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 21},
  pages={9886-90}
}
Because of the ability of certain long-chain polyunsaturated fatty acids (PUFAs) to prevent lethal cardiac arrhythmias, we have examined the effects of various long-chain fatty acids on the contraction of spontaneously beating, isolated, neonatal rat cardiac myocytes. The omega 3 PUFA from fish oils, eicosapentaenoic acid [EPA; C20:5 (n-3)] and docosahexaenoic acid [DHA; C22:6 (n-3)], at 2-10 microM profoundly reduced the contraction rate of the cells without a significant change in the… CONTINUE READING