Effects of long-acting somatostatin analogues on adrenal growth and phosphoribosyl pyrophosphate formation in experimental diabetes.

@article{Kunjara2012EffectsOL,
  title={Effects of long-acting somatostatin analogues on adrenal growth and phosphoribosyl pyrophosphate formation in experimental diabetes.},
  author={Sirilaksana Kunjara and Alexandra Greenbaum and Milena Sochor and Murad Ali and Allan Flyvbjerg and H Gr{\o}nbaek and Paul J. Mclean},
  journal={International journal of experimental pathology},
  year={2012},
  volume={93 1},
  pages={
          56-69
        }
}
Adrenal growth and increased adrenal function occur in experimental diabetes. Previously, we have shown that phosphoribosyl pyrophosphate (PRPP) and PRPP synthetase increased rapidly between 3 and 7 days after induction of diabetes with streptozotocin (STZ), with less marked changes in enzymes of the pentose phosphate pathway. The present study examines the earlier phase of 1-3 days following induction of diabetes, seeking to elucidate whether control of PRPP production is a result of diabetic… CONTINUE READING
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