Effects of long‐term treatment with the anti‐androgen bicalutamide on human testis: an ultrastructural and morphometric study

@article{Morgante2001EffectsOL,
  title={Effects of long‐term treatment with the anti‐androgen bicalutamide on human testis: an ultrastructural and morphometric study},
  author={Emanuela Morgante and Roberto Gradini and Massimo Realacci and Patrizio Sale and G D'eramo and G A Perrone and Maria Rosaria Cardillo and Elisa Petrangeli and Matteo Antonio Russo and Franco di Silverio},
  journal={Histopathology},
  year={2001},
  volume={38}
}
To assess the effects of more than 4 years' treatment with the anti‐androgen bicalutamide on human testis by clinical, ultrastructural and morphometric analysis. 

Impact of bicalutamide, an anti-androgen on rat testis

Treatment with bicalutamide induced various biochemical, histological and immunological changes in rat testis, and non-significant decrease in relative testis weight was caused.

Short-term antiandrogen flutamide treatment causes structural alterations in somatic cells associated with premature detachment of spermatids in the testis of pubertal and adult guinea pigs.

The transient exposition of the guinea pigs to flutamide, at all postnatal ages causes some degenerative lesions including severe premature detachment of spermatids and accumulation of myelin bodies in Leydig and Sertoli cells, compromising, at least temporarily, the sPermatogenesis.

Flutamide treatment reveals a relationship between steroidogenic activity of Leydig cells and ultrastructure of their mitochondria

It is demonstrated that increase in the expression level of steroidogenic proteins in rat testicular tissue as well as elevation of intratesticular sex steroid hormone levels observed in treated animals correspond well to morphological alterations of the Leydig cell ultrastructure.

FDA-approved drugs that are spermatotoxic in animals and the utility of animal testing for human risk prediction

The current animal models are not very effective for predicting human spermatotoxicity, and there is limited information available about the impact of many drugs on human spermatozoa.

Etude du ligand TRAIL et ses récepteurs dans la prostate normale et pathologique reliée au statut hormonal

Dans un modele de cancer prostatique humain hormonosensible greffe chez la souris nude traitee par un anti-androgene nous montrons l'expression des recepteurs au TRAIL, et de certains genes renseignant sur the relation entre croissance tumorale et statut hormonal.

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