Effects of localized neurotrophin gene expression on spiral ganglion neuron resprouting in the deafened cochlea.

@article{Wise2010EffectsOL,
  title={Effects of localized neurotrophin gene expression on spiral ganglion neuron resprouting in the deafened cochlea.},
  author={Andrew K. Wise and Clifford R. Hume and Brianna O. Flynn and Yogesh S Jeelall and Courtney L. Suhr and Beatrice E Sgro and Stephen J. O'Leary and Robert K. Shepherd and Rachael T. Richardson},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2010},
  volume={18 6},
  pages={1111-22}
}
A cochlear implant may be used to electrically stimulate spiral ganglion neurons (SGNs) in people with severe sensorineural hearing loss (SNHL). However, these neurons progressively degenerate after SNHL due to loss of neurotrophins normally supplied by sensory hair cells (HCs). Experimentally, exogenous neurotrophin administration prevents SGN degeneration but can also result in abnormal resprouting of their peripheral fibers. This study aimed to create a target-derived neurotrophin source to… CONTINUE READING

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Morphological changes in spiral ganglion cells after intracochlear application of brain-derived neurotrophic factor in deafened guinea pigs

MJ Agterberg, H Versnel, +3 authors SF Klis
Hear Res • 2008

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