Effects of localized HLA class II beta chain polymorphism on binding of antigenic peptide and stimulation of T cells.

@article{NewtonNash1992EffectsOL,
  title={Effects of localized HLA class II beta chain polymorphism on binding of antigenic peptide and stimulation of T cells.},
  author={Debra K. Newton-Nash and David D. Eckels},
  journal={Human immunology},
  year={1992},
  volume={33 3},
  pages={213-23}
}
The relationship between HLA-DR1 polymorphism and recognition of antigen by T cells was investigated. Two allelic variants of HLA-DR1, which differ by amino acid substitution at positions 85 and 86 of the beta chain, were characterized for the effect of substitution on recognition of foreign antigen by DR1-restricted T cells. Substitution of alanine and valine for valine and glycine residues at positions 85 and 86 of the DR1 beta chain resulted in deficient T-cell stimulation as demonstrated by… CONTINUE READING